GABA_BResponse Class Reference

#include <GABA_BResponse.h>

Inheritance diagram for GABA_BResponse:

Collaboration diagram for GABA_BResponse:

List of all members.

Public Member Functions

GABA_BResponse ()

virtual ~GABA_BResponse ()

virtual int reset (double dt)

Called at the beginning of a simulation at t=0.

virtual int advance (AdvanceInfo const &ai)

Calculate the next state and output/propagate the result to succesors/outgoing objects.

virtual int spikeHit (spikeport_t port, SpikeEvent const &spike)

virtual int psrLength (double dt) const

The lengh of the postsynaptic response (in time steps).

Public Attributes

double k1

Binding rate for transmitter substance in the cleft to receptors [range=(0,1); units=ms^-1;].

double k2

Unbinding rate for the transmitter substance to the receptors.

double k3

Binding rate for the G-proteins to the K+ channel.

double k4

Unbinding rate for the G-proteins to the K+ channel.

double kd

Dissociation constant of binding G-protein to K+ channels.

int n

Number of individual binding sites for the G-protein in a singel K+ channel.

double Cmax

max. amount of Transmitter in the synaptic cleft

double Cdur

Transmitter duration.

double dead_time

min. time between release events

double r

Fraction of activated receptors.

double s

Concentration of G-proteins binded to K+ channels.

double time_count

double g_max

Protected Attributes

double C1_on

double C1_off

double C2_on

double C3

double C4

Detailed Description

Definition at line 11 of file GABA_BResponse.h.

Constructor & Destructor Documentation

GABA_BResponse::GABA_BResponse ( )

Definition at line 3 of file GABA_BResponse.cpp.

References Cdur, Cmax, dead_time, g_max, k1, k2, k3, k4, kd, and n.

virtual GABA_BResponse::~GABA_BResponse ( ) [inline, virtual]

Definition at line 16 of file GABA_BResponse.h.

Member Function Documentation

int GABA_BResponse::reset ( double dt ) [virtual]

Called at the beginning of a simulation at t=0.

Reimplemented from FiniteSpikeResponse.

Reimplemented in DynamicNonLinGABAExpSynapse, StaticNonLinGABAExpSynapse, GenericNonLinGABASynapse< Response >, GenericDynamicSpikingSynapse< GenericNonLinGABASynapse< ExponentialDecaySpikeResponse > >, and GenericNonLinGABASynapse< ExponentialDecaySpikeResponse >.

Definition at line 19 of file GABA_BResponse.cpp.

References C1_off, C1_on, C2_on, C3, C4, Cmax, dead_time, k1, k2, k4, r, FiniteSpikeResponse::reset(), s, and time_count.

Referenced by GenericNonLinGABASynapse< ExponentialDecaySpikeResponse >::reset().

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int GABA_BResponse::advance ( AdvanceInfo const & ) [virtual]

Calculate the next state and output/propagate the result to succesors/outgoing objects.

The return value of advance contains several bits of information which can be decoded with the bit masks ADVANCEFLAG_* like ADVANCEFLAG_HASSPIKED and ADVANCEFLAG_DEACTIVATE.

Reimplemented from SimObject.

Reimplemented in GenericNonLinGABASynapse< Response >, GenericConductanceBasedSpikingSynapse< GABA_BResponse >, and GenericNonLinGABASynapse< ExponentialDecaySpikeResponse >.

Definition at line 41 of file GABA_BResponse.cpp.

References FiniteSpikeResponse::advanceReturn(), C1_off, C1_on, C2_on, C3, C4, AdvanceInfo::dt, g_max, Time::in_sec(), k3, kd, n, FiniteSpikeResponse::psr, r, s, and time_count.

Referenced by GenericNonLinGABASynapse< ExponentialDecaySpikeResponse >::advance().

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int GABA_BResponse::spikeHit	(	spikeport_t	port,
		SpikeEvent const &	spike
	)			`[virtual]`

Function to be called if the object is hit by a spike Called by spike exchange mechanims if a spike hits (arrives at) the object A return value of greater 0 indicates that the object is currently not active and the sim engine has to put this object into its list of active spike receivers. A return value of 0 indicates the the object is currently active (i.e. is already in the list of active receviers) and need not to be put into the list of active synapses.

Reimplemented from SimObject.

Reimplemented in GenericNonLinGABASynapse< Response >, GenericDynamicSpikingSynapse< GenericNonLinGABASynapse< ExponentialDecaySpikeResponse > >, GenericNonLinGABASynapse< ExponentialDecaySpikeResponse >, GenericStaticSpikingSynapse< GenericNonLinGABASynapse< ExponentialDecaySpikeResponse > >, and GenericStaticSpikingSynapse< GenericConductanceBasedSpikingSynapse< GABA_BResponse > >.

Definition at line 57 of file GABA_BResponse.cpp.

References Cdur, dead_time, SpikeEvent::dt, FiniteSpikeResponse::spikeHitReturn(), and time_count.

Referenced by GenericNonLinGABASynapse< ExponentialDecaySpikeResponse >::spikeHit().

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int GABA_BResponse::psrLength ( double dt ) const [virtual]

The lengh of the postsynaptic response (in time steps).

Implements FiniteSpikeResponse.

Definition at line 72 of file GABA_BResponse.cpp.

References PSR_MULTIPLE_TAU.

Member Data Documentation

double GABA_BResponse::k1

Binding rate for transmitter substance in the cleft to receptors [range=(0,1); units=ms^-1;].

Definition at line 20 of file GABA_BResponse.h.

Referenced by DynamicNonLinGABAExpSynapse::DynamicNonLinGABAExpSynapse(), GABA_BResponse(), GABA_BSynapse::GABA_BSynapse(), reset(), and StaticNonLinGABAExpSynapse::StaticNonLinGABAExpSynapse().

double GABA_BResponse::k2

Unbinding rate for the transmitter substance to the receptors.

Definition at line 22 of file GABA_BResponse.h.

Referenced by DynamicNonLinGABAExpSynapse::DynamicNonLinGABAExpSynapse(), GABA_BResponse(), GABA_BSynapse::GABA_BSynapse(), reset(), and StaticNonLinGABAExpSynapse::StaticNonLinGABAExpSynapse().

double GABA_BResponse::k3

Binding rate for the G-proteins to the K+ channel.

Definition at line 25 of file GABA_BResponse.h.

Referenced by advance(), DynamicNonLinGABAExpSynapse::DynamicNonLinGABAExpSynapse(), GABA_BResponse(), GABA_BSynapse::GABA_BSynapse(), and StaticNonLinGABAExpSynapse::StaticNonLinGABAExpSynapse().

double GABA_BResponse::k4

Unbinding rate for the G-proteins to the K+ channel.

Definition at line 27 of file GABA_BResponse.h.

Referenced by DynamicNonLinGABAExpSynapse::DynamicNonLinGABAExpSynapse(), GABA_BResponse(), GABA_BSynapse::GABA_BSynapse(), reset(), and StaticNonLinGABAExpSynapse::StaticNonLinGABAExpSynapse().

double GABA_BResponse::kd

Dissociation constant of binding G-protein to K+ channels.

Definition at line 30 of file GABA_BResponse.h.

Referenced by advance(), DynamicNonLinGABAExpSynapse::DynamicNonLinGABAExpSynapse(), GABA_BResponse(), GABA_BSynapse::GABA_BSynapse(), and StaticNonLinGABAExpSynapse::StaticNonLinGABAExpSynapse().

int GABA_BResponse::n

Number of individual binding sites for the G-protein in a singel K+ channel.

Definition at line 33 of file GABA_BResponse.h.

Referenced by advance(), DynamicNonLinGABAExpSynapse::DynamicNonLinGABAExpSynapse(), GABA_BResponse(), GABA_BSynapse::GABA_BSynapse(), and StaticNonLinGABAExpSynapse::StaticNonLinGABAExpSynapse().

double GABA_BResponse::Cmax

max. amount of Transmitter in the synaptic cleft

Definition at line 36 of file GABA_BResponse.h.

Referenced by DynamicNonLinGABAExpSynapse::DynamicNonLinGABAExpSynapse(), GABA_BResponse(), GABA_BSynapse::GABA_BSynapse(), reset(), and StaticNonLinGABAExpSynapse::StaticNonLinGABAExpSynapse().

double GABA_BResponse::Cdur

Transmitter duration.

Definition at line 39 of file GABA_BResponse.h.

Referenced by DynamicNonLinGABAExpSynapse::DynamicNonLinGABAExpSynapse(), GABA_BResponse(), GABA_BSynapse::GABA_BSynapse(), spikeHit(), and StaticNonLinGABAExpSynapse::StaticNonLinGABAExpSynapse().

double GABA_BResponse::dead_time

min. time between release events

Definition at line 42 of file GABA_BResponse.h.

Referenced by DynamicNonLinGABAExpSynapse::DynamicNonLinGABAExpSynapse(), GABA_BResponse(), GABA_BSynapse::GABA_BSynapse(), reset(), spikeHit(), and StaticNonLinGABAExpSynapse::StaticNonLinGABAExpSynapse().

double GABA_BResponse::r

Fraction of activated receptors.

Definition at line 45 of file GABA_BResponse.h.

Referenced by advance(), and reset().

double GABA_BResponse::s

Concentration of G-proteins binded to K+ channels.

Definition at line 48 of file GABA_BResponse.h.

Referenced by advance(), and reset().

double GABA_BResponse::time_count

Definition at line 58 of file GABA_BResponse.h.

Referenced by advance(), reset(), and spikeHit().

double GABA_BResponse::g_max

Definition at line 60 of file GABA_BResponse.h.

Referenced by advance(), DynamicNonLinGABAExpSynapse::DynamicNonLinGABAExpSynapse(), GABA_BResponse(), GABA_BSynapse::GABA_BSynapse(), StaticNonLinGABAExpSynapse::reset(), DynamicNonLinGABAExpSynapse::reset(), and StaticNonLinGABAExpSynapse::StaticNonLinGABAExpSynapse().

double GABA_BResponse::C1_on [protected]

Definition at line 63 of file GABA_BResponse.h.

Referenced by advance(), and reset().

double GABA_BResponse::C1_off [protected]

Definition at line 63 of file GABA_BResponse.h.

Referenced by advance(), and reset().

double GABA_BResponse::C2_on [protected]

Definition at line 63 of file GABA_BResponse.h.

Referenced by advance(), and reset().

double GABA_BResponse::C3 [protected]

Definition at line 63 of file GABA_BResponse.h.

Referenced by advance(), and reset().

double GABA_BResponse::C4 [protected]

Definition at line 63 of file GABA_BResponse.h.

Referenced by advance(), and reset().

The documentation for this class was generated from the following files:

/home/tnatschl/PCSIM-Sandbox/pcsim/pcsim/simobjects/GABA_BResponse.h
/home/tnatschl/PCSIM-Sandbox/pcsim/pcsim/simobjects/GABA_BResponse.cpp


Public Member Functions
	GABA_BResponse ()
virtual	~GABA_BResponse ()
virtual int	reset (double dt)
	Called at the beginning of a simulation at t=0.
virtual int	advance (AdvanceInfo const &ai)
	Calculate the next state and output/propagate the result to succesors/outgoing objects.
virtual int	spikeHit (spikeport_t port, SpikeEvent const &spike)
virtual int	psrLength (double dt) const
	The lengh of the postsynaptic response (in time steps).
Public Attributes
double	k1
	Binding rate for transmitter substance in the cleft to receptors [range=(0,1); units=ms^-1;].
double	k2
	Unbinding rate for the transmitter substance to the receptors.
double	k3
	Binding rate for the G-proteins to the K+ channel.
double	k4
	Unbinding rate for the G-proteins to the K+ channel.
double	kd
	Dissociation constant of binding G-protein to K+ channels.
int	n
	Number of individual binding sites for the G-protein in a singel K+ channel.
double	Cmax
	max. amount of Transmitter in the synaptic cleft
double	Cdur
	Transmitter duration.
double	dead_time
	min. time between release events
double	r
	Fraction of activated receptors.
double	s
	Concentration of G-proteins binded to K+ channels.
double	time_count
double	g_max
Protected Attributes
double	C1_on
double	C1_off
double	C2_on
double	C3
double	C4